Combating Diabetes and its Emerging Complications Utilizing Natural Phytochemicals
Introduction: Natural phytochemicals are considered a primary health care measure for many
chronic diseases and for assurance of urban health and wellbeing. Diabetes and its related
complications are major chronic diseases increasingly threatening human health and wellbeing.
Till date, these diseases are not fully managed by the current therapies. Thus, there is an
increasing need to find more safe and efficient therapies for diabetes and its related complications.
Methods: An evidence-based review of the novel phytotherapies to diabetes and its
related complications and discussing their main mechanisms of actions are the main aims
of the current study. Data collection were done for the phytotherapies that were extracted,
chromatographically standardized, fractionated and the main effective compounds were
isolated and evaluated for their potentials against diabetes and its related complications.
Special emphasis was given for the extracts and their isolated phytochemicals that had
significant hypoglycemic and antinociceptive effects towards diabetes and its related
complications, particularly diabetic-neuropathy. Results: The phytochemicals main mechanisms
of action were found to be mainly due to their insulin secretagogue, beta-cells regeneration,
anti-oxidant potentials. Conclusion: Therefore, clinicians should consider natural phytochemicals
when treating chronic diseases and when reassuring better urban health and wellbeing.
Key words: Combating Diabetes, Emerging Complication, Natural Phytochemicals Mechanism
of action, Complementary medicine.
Pharmacognosy Journal,DOI: 10.5530/pj.2019.11.2, ISSN: 0975-3575, Volume: 11, Issue: 2, Pages Range: 73-77,