Validated kinetic spectrophotometric determination of candesartan cilexetil and olmesartan medoxomil using alkaline permanganate oxidation


A simple and sensitive kinetic method is described for the determination of two hypotensive drugs belonging to the angiotensin II antagonist Candesartan Cilexetil (CAN) and Olmesartan Medoxomil(OLM). This method is based upon a kinetic investigation of drug oxidation with alkaline potassium permanganate. All variables affecting color development have been investigated and the conditions optimized. The kinetic rate was obeying pseudo-first order reaction. Among the methods applied were the Initial rate, Rate constant, Fixed-concentration and Fixed-time methods. Accounting for the applicability, the sensitivity, values of correlation coefficient (r) and intercept (a), the Fixed-time method is selected for these two drugs assay. The absorbance-concentration plots were rectilinear within the range of 5-30 ug.mL-1for CAN and20-60 ug.mL-1for OLM. The statistical data for the results challenged for the robustness of the fixed-time method. Keywords: Candesartan Cilexetil; Olmesartan Medoxomil; Kinetic; Spectrophotometry; Determination


Marwa K. El Jamal


M. Abdelhady El Sayed, Ekram M. Hassan

Journal/Conference Information

Der Pharma Chemica, 6(2):122-133