Drug Interaction between Azithromycin and Diltiazem may cause a QTc Interval Prolongation: a case report


Azithromycin is widely prescribed for the treatment of respiratory tract infections. Incidence of corrected QT interval (QTc) prolongation and cardiac arrest has not been reported after concomitant administration of azithromycin and diltiazem. Here we present a 69-year-old female patient who developed profound QTc prolongation and cardiac arrest after three days of concomitant administration of azithromycin and diltiazem. The patient was successfully resuscitated, intravenous magnesium was given and azithromycin therapy was discontinued. The QTc interval dropped to 412 ms 24 hours after azithromycin discontinuation. One week later, the patient was discharged home after full recovery. This case illustrates a possible drug interaction between azithromycin and P-glycoprotein inhibitor drugs and/or drugs having an effect on cardiac repolarization. Key words: Azithromycin, Diltiazem, Drug Interaction, QTc prolongation, Torsade de pointes, Cardiac arrest


Lama Soubra


Ali Mroueh, Samer Kabbani

Journal/Conference Information

International Journal of Basic and Clinical Pharmacology,3(1): 242-246