Background: Acrylamide (ACR) is known neurotoxin and carcinogen linked to frying and baking meals high in carbohydrates and is frequently present in soils and groundwater. It is used to create polymers for industry. Pregnant women are exposed to ACR through food, and their fetuses likely to be harmed. Vitamin E is significant lipid-soluble vitamin found in nature and essential for numerous physiological activities. Aim: to examine effects of exposure to acrylamide on skeletal development of rat embryos and the potential role of Vitamin E (Vit. E) in the reduction of these effects. Methods: 40 pregnant albino rats were divided to four groups where control group administrated distilled water orally. Low ACR group administrated acrylamide (10 mg/kg/day) via gavage from GD 1 to GD20. High ACR group administrated acrylamide (30 mg/kg/day) from GD 1 to GD 20. ACR vit. E group administrated 100 mg/kg of vitamin E and 30 mg/kg of ACR orally. Alizarin red and Alcian blue stains used to double-stain the skeletons, then examined by dissecting stereomicroscope. Results: Skeletal anomalies found were incomplete and un-ossified bones of skull, sacral vertebrae, ribs, bones of forelimb and hind limb, unossified carpals, metacarpals, tarsals, metatarsals, and phalanges. These were obvious in ACR treated groups compared to control group and improved in ACR vitamin E group. Conclusion: Acrylamide caused skeletal congenital abnormalities thus prove its teratogenicity and vitamin E seems to protect against and reduce such abnormalities.