Abstract This study aimed to explore the differences in menopausal symptoms and neuroticism between two samples of Lebanese and Egyptian women who have already reached menopause. The sample constituted 191 women in the Lebanese (N=90) and Egyptian (N=101) societies. The scales used were the Menopause Symptoms Questionnaire (MSQ) (Abdel-Khalek & El Nayal, 1990) and the Factorial Arabic Neuroticism Scale (Abdel-Khalek, 2009). The Lebanese sample scored a significantly higher mean score compared to their Egyptian counterparts on the total MSQ as well as 12 symtoms, and neuroticism. The results of the study were discussed in the light of previous studies, as well as the social circumstances of the samples. It was concluded that it is essential to conduct further cross-cultural research to understand the nature of menopausal symptoms in other countries, as well as setting interventive programs to develop women’s skills in combating menopausal symptoms. Keywords: Menopause, Neuroticism, Women, Lebanon,Egypt.