Quality of life (QOL) is a basic concept in a number of disciplines, including social sciences, politics, economics, the environment, psychology, and medicine. Although the term comprises primarily psychological components, it remains a multi-dimensional concept that has been derived from various fields, the most important of which are biology, medicine, psychology, and sociology. Well-being generally includes global judgments of life satisfaction and feelings ranging from depression to joy. The study sought to (1) investigate the sex-related differences on both quality of life (QOL) and well-being. A convenience sample of 382 adults from the Palestinian and Syrian refugees were recruited. The study used the Arabic version of the World Health Organization Quality of Life-Brief (WHOQOL-Brief) scale. Derived from the original 100-item WHOQOL-100 scale, it is a 26-item questionnaire that covers four domains related to QOL: physical health, psychological health, social relationships and the environment. The well-being self-report scale is applied on the research sample. The results of the study are discussed in the light of the previous studies and the theoretical frame work relevant to Quality of life and well-being Based upon the findings of the present study, it was recommended to develop a guidance program aimed to raise the adults awareness of the importance of quality of life and its impact on the well-being.