This study sought to investigate the sex-related differences on both quality of life (QOL) and insomnia, and estimate the correlations and the factorial structure of the study variables. Participants were Lebanese university students (N= 215: 125 men & 90 women). They responded to the Arabic short version of the WHO Quality of Life Scale, and the Arabic Scale of Insomnia. The study showed no significant differences between men and women on the mean scores on either the QOL or the insomnia scales. All the correlations between the insomnia scale and the QOL subscales and the total scale were statistically significant and negative. Principal components analysis identified one bipolar factor, labeled “Quality of life vs. insomnia” in men, women and the whole sample. It was concluded that insomnia may have an impact on the quality of life in university students. Based upon the findings of the present study, it was recommended to develop a guidance program aimed to raise students’ awareness of the importance of the self-management of insomnia problem because of its impact on quality of life. Keywords: Quality of Life; Insomnia; University Students; Lebanon