Aim: The present study aimed to assess knowledge and attitudes toward STDs among Beirut Arab University (BAU) students. Methods: A QR code linked to the Google Forms questionnaire was scanned by the students and an explanation about the project was provided to the targeted sample. The data collection form included socio-demographics, as well as knowledge and attitudes scale about STDs. Results: A total of 414 students were included in the study. The findings revealed that 80.5% of the students had moderate to high knowledge levels. Age, marital status, and faculty were found to be linked to knowledge levels, where older, married, and those in health-related fields scored higher. Furthermore, our study results showed that students have a neutral attitude toward STDs, so 50% of attitude scores were greater than 3.625. Moreover, the current study found that higher students’ knowledge scores were linked to better students’ attitudes toward STDs. Conclusion: The findings indicated that the overall knowledge level tends to be moderate to high, but specific knowledge gaps still exist about sexually transmitted diseases; this issue should be addressed during sex education. On the other hand, the overall students’ attitudes towards STDs tend to be neutral with some misconceptions.