This study was conducted to evaluate the compressive strength, compressive fatigue limit and the amount of fluoride released from the Smart Dentin Replacement SDRTM restorative material in comparison to another fluoride released from hybrid resin composite material Tetric N Ceram. A total of eighty (80) specimens were used in this study, where forty (40) specimens were used to evaluate the compressive strength and the compressive fatigue limit, while the other forty (40) specimens were used to evaluate the amount of fluoride released from the two tested materials. Each of the forty (40) specimens for the two tests was divided into two groups: where Group (1) represented the Tetric N Ceram material, and Group (2) represented the SDR TM. Statistically significant difference was found between the mean of the compressive strength of the specimens in Group (1) and Specimens of Group (2) as they recorded 224 ± 8.4 and 201.6 ± 9.05 respectively. While, no statistically significant difference was found between the mean of compressive fatigue limit of the specimens in Group (1) and Specimens of Group (2) as they recorded 188.5 ± 6.2 and 190 ± 5.02 respectively. Results also revealed that the mean Compressive fatigue limit of the SRDTM caped with 2 mm of Tetric N Ceram was approximately 94.52% from its Compressive bond strength means. Fluoride release test revealed the significant superior results of fluoride released by the SDR TM. Smart dentine replacement caped with hybrid resin composite could be the material of choice when the amount fluoride released is considered in selection of tooth restoration and when the proper functioning in the oral cavity is required for a permanent restoration in stress areas. Also it was concluded that the SDR TM ability to release fluoride was more than the Tetric N Ceram. Key Words: Compressive strength; Fatigue limit, Fluoride release