Science - Course - Epigenetics and Cancer

This course deals with the concept of epigenetics and how it regulates gene expression and heritable phenotypes without changes in the underlying DNA sequence. It provides a mechanistic overview with discussion topics including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs as key players in the process of carcinogenesis. It covers molecular techniques and model organisms used commonly in epigenetics research. Students will be able to understand the epigenetic basis of various developmental disorders, the natural aging process, environmental exposures, and relevant human diseases such as tumorigenesis, obesity, neurological disorders, and infections.