2024
- Green Synthesis of Yttrium Derivatives Nanoparticles Using Pine Needle Leaf Extract: Characterization, Docking, Antibacterial, and Antioxidant Potencies. Nourhane A Darwich, Malak Mezher, Alaa M Abdallah, Ahmed F El-Sayed, Rana El Hajj, Taymour A Hamdalla, Mahmoud I Khalil. Processes 12 (8), 1713, 2024. https://doi.org/10.3390/pr12081713
- Isolation and Characterization of Bacillus Subtilis BSP1 from Soil: Antimicrobial Activity and Optimization of Fermentation Conditions. Heba Hellany, Jean Claude Assaf, Sara Barada, Dalia el-Badan, Rana El Hajj, Sonia Abou Najem, Antoine G Abou Fayad, Mahmoud I Khalil. Processes 12 (8), 1621, 2024. https://doi.org/10.3390/pr12081621
- Uncovering the Therapeutic Potential of Lithium Chloride in Type 2 Diabetic Cardiomyopathy: Targeting Tau Hyperphosphorylation and TGF-β Signaling via GSK-3β Inhibition. Layal Abou Assi, Sahar Alkhansa, Rachel Njeim, Jaafar Ismail, Mikel Madi, Hilda E Ghadieh, Sarah Al Moussawi, Tanya S Azar, Maurice Ayoub, William S Azar, Sarah Hamade, Rashad Nawfal, Nina-Rossa Haddad, Frederic Harb, Wissam Faour, Mahmoud I Khalil, Assaad A Eid. Pharmaceutics 16 (7), 955, 2024. https://doi.org/10.3390/pharmaceutics16070955
- Microbial Decontamination of Cuminum cyminum Seeds Using "Intensification of Vaporization by Decompression to the Vacuum": Effect on Color Parameters and Essential Oil Profile. Hana Tannir, Espérance Debs, Georges Mansour, Susanne Neugart, Rima El Hage, Mahmoud I Khalil, Nada El Darra, Nicolas Louka. Foods 13 (14), 2264, 2024. https://doi.org/10.3390/foods13142264. PMid:39063348 PMCid:PMC11275638
- Valorization of sesame seed coat waste: phenolic composition, antibacterial efficacy, and nanoemulsion encapsulation for food preservation. S Khazaal, Mahmoud I. Khalil, TM Osaili, B Albiss, AA Al-Nabulsi, N Louka. Frontiers in Nutrition 11, 1405708. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1405708/full
- Rosemary essential oil potentiates the antitumour activity of 5-fluorouracil in human colorectal carcinoma cells. AA El Sala, G Khawaja, Mahmoud I. Khalil, SA Salam. Journal of Pharmacy and Pharmacology 76 (6), 691-700, 2024. https://doi.org/10.1093/jpp/rgae022 PMid:38459835
- Valorization of sesame (Sesamum indicum L.) seed coats: Optimization of polyphenols' extraction using Ired-Irrad® and assessment of their biological activities. S Khazaal, N Louka, E Debs, Mahmoud I. Khalil, B Albiss, AA Al-Nabulsi, Journal of Agriculture and Food Research 16, 101105, 2024. https://doi.org/10.1016/j.jafr.2024.101105
- Antibacterial and Antifungal Activities of Cimbopogon winterianus and Origanum syriacum Extracts and Essential Oils against Uropathogenic Bacteria and Foodborne Fungal Isolates. M Rammal, S Khreiss, A Badran, M Mezher, M Bechelany, C Haidar, Mahmoud I. Khalil. Foods 13 (11), 1684, 2024. PMCid:PMC11171924 https://doi.org/10.3390/foods13111684
- Fungal Isolation, Detection, and Quantification of Aflatoxins in Nuts Sold in the Lebanese Market. H Hellany, JC Assaf, J Matta, Mahmoud I. Khalil. Processes 12 (5), 1018, 2024. https://doi.org/10.3390/pr12051018
- The modulatory effect of Al-Assi river trout fish meal on OCD manifestations and molecular mechanisms in BALB/c Mice. F Salloum, M Farran, H Shaib, A Jurjus, R Sleiman, Mahmoud I. Khalil. Functional Foods in Health and Disease 14 (5), 299-310, 2024. https://doi.org/10.31989/ffhd.v14i5.1321
- Magnetic separation, sunlight-driven photocatalytic activity, and antibacterial studies of Sm-doped Co0.33Mg0.33Ni0.33Fe2O4 nanoparticles. A Aridi, M Rabaa, M Mezher, D Naoufal, Mahmoud I. Khalil, R Awad. Environmental Science and Pollution Research, 1-20, 2024. PMID: 38739338 https://doi.org/10.1007/s11356-024-33641-y
- Optimization of Aqueous Extraction of Polyphenols from Cuminum cyminum Seeds Using Response Surface Methodology and Assessment of Biological Activity. H El Tannir, D Houhou, E Debs, M Koubaa, A Jammoul, B Azakir, Mahmoud I. Khalil. BioTech 13 (1), 7, 1, 2024. PMid:38534916 PMCid: PMC10968084 https://doi.org/10.3390/biotech13010007
- Characterization, antioxidant, antibacterial, and antibiofilm properties of biosynthesized Ag/AgCl nanoparticles using Origanum ehrenbergii Boiss. Z Hachem, R Kashmar, AM Abdallah, R Awad, Mahmoud I. Khalil. Results in Materials 21, 100550, 2024. https://doi.org/10.1016/j.rinma.2024.100550
- Characterization of Actinobacteria strains in Lebanese soil with an emphasis on investigating their antibacterial activity. R Zahr, S Zahr, R El Hajj, Mahmoud I. Khalil. Brazilian Journal of Microbiology, 1-13, 2024. PMID: 38228935 PMCID: PMC10920600 https://doi.org/10.1007/s42770-023-01242-5
- Fabrication, characterization, and antibacterial activity of ferrite, chromite, and aluminate nanoparticles. I El Hajjar, M Al Bitar, R Zahr, S Zahr, Mahmoud I. Khalil, R Awad. Materials Research Express 11 (1), 015003, 1, 2024. https://doi.org/10.1088/2053-1591/ad1774
- T. Boudieri Extract Potentiates the Effects Of Capecitabine Treatment In Human Colon Cancer Cells. Katia Sawaya, Mahmoud I. Khali, and Ghada Khawaja. BAU Journal-Science and Technology 5.2 (2024): 10.
https://doi.org/10.54729/2959-331X.1133
- Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection. F Salloum, M Farran, H Shaib, A Jurjus, R Sleiman, Mahmoud I. Khalil. Behavioural Neurology 2024 (1), 4504858, 2024. https://doi.org/10.1155/2024/4504858 PMid:38566972 PMCid:PMC10985275
Health and Wellbeing Theme:
Studying human disorders at the molecular level (subtheme)
- [2023] Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function. Int. J. Mol. Sci. 2023, 24(10), 8806. Mahmoud Khalil, Heba M. Ismail, Ganna Panasyuk, Anna Bdzhola, Valeriy Filonenko, Ivan Gout, Olivier E. Pardo
- [2023] Biological Factors Underpinning Suicidal Behaviour: An Update. Brain Sciences. 2023; 13(3):505. Maya Abou Chahla, Mahmoud Khalil, Stefano Comai, Lena Brundin, Sophie Erhardt, Gilles J. Guillemin.
- [2023] Proapoptotic and Antiproliferative Effects of the Desert Truffle Terfezia boudieri on Colon Cancer Cell Lines. Evid Based Complement Alternat Med, Volume (2023), Article ID 1693332. Katia Sawaya, Sonia Abou Najem, Ghada Khawaja, Mahmoud Khalil
- [2022] Effects of continuous prenatal and postnatal global system for mobile communications electromagnetic waves (GSM-EMW) exposure on the oxidative stress biomarkers in female rat liver. Heliyon 8, no. 12 (2022): e12367. Mariam Salameh, Sukaina Zeitoun-Ghandour, Lina Sabra, Lina Ismail, Ahmad Daher, Ali Bazzi, Mahmoud Khalil, Wissam Joumaa
- [2022] Beneficial role of naringin against methotrexate-induced injury to rat testes: biochemical and ultrastructural analyses. Redox Report 27, no. 1 (2022): 158-166. Hany Elsawy, Abdullah M Alzahrani, Manal Alfwuaires, Ashraf M Abdel-Moneim, Mahmoud Khalil
- [2022] Insights into COVID-19 Vaccines Development: Translation From Benchside to Bedside. Health Sciences Review, 4:100040. Marwa Houssein, Aya El Asir Al Hossainy, Jana Al soussi, Jana El Batch, Lana El-Samadi, Sherine El Imam, Rawan Fakih, Hoda Dakdouk, Mahmoud Khalil
- [2022] Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain. Neurotoxicology and Teratology (2022): 107095. Mohammad H. Merii, Manal M. Fardoun, Khalil El Asmar, Mahmoud Khalil, Ali H. Eid, Hassan R. Dhaini.
- [2021] Combination of docosahexaenoic acid and Ginko biloba extract improves cognitive function and hippocampal tissue damages in a mouse model of Alzheimer's disease. Journal of Chemical Neuroanatomy, Volume 116, October 2021, 101995 Nabila Abdelmeguid, Mahmoud Khalil, Rasha Elhabet, Ahmed Sultan, Sherine Abdel Salam
- [2021] Nephroprotective effect of naringin in methotrexate induced renal toxicity in male rats. Biomedicine & Pharmacotherapy, Volume 143, November 2021, 112180. Hany Elsawy, Abdullah M. Alzahrani, Manal Alfwuaires, Ashraf M. Abdel-Moneim, Mahmoud Khalil.
- [2021] Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers. Journal of Chemical Neuroanatomy, Volume 115, September 2021, Hany Elsawy, Abdullah Alzahrani, Manal Alfwuaires, Azza Sedky, Eman El-Trass, Omar Mahmoud, Ashraf Abdel-Moneim, Mahmoud Khalil.
- [2020] Apoptosis as a mechanism for treatment of Adult T cell Leukemia: Promising drugs from benchside to bedside. Drug Discovery Today. (2020) 25 (7), 1189-1197. Marwa Houssein, Mahmoud Khalil, Maamoun Fatfat, Hala Gali-Muhtasib
- [2020] Thymoquinone synergizes with arsenic and interferon alpha to target human T-cell leukemia/lymphoma. Life Sciences. (2020) 251, ID 117639. Marwa Houssein, Maamoun Fatfat, Zeina Habli, Nasab Ghazal, Sara Mokdad, Hala Khalife, Mahmoud Khalil, Hala Gali-Muhtasib.
- [2019] Impacts of prolonged chlorpyrifos exposure on locomotion and slow-and fast- twitch skeletal muscles contractility in rats. Toxicology Reports, 6, 598-606 (2019). Nancy Hallal, Hiba Sabbouri, Ali Salami, Wiam Ramadan, Hassan Khachfe, Mohamed Moustafa, Mahmoud Khalil, Wissam Joumaa.
- [2017] Developing Spindlin1 Small Molecule Inhibitors Using Protein Microarrays. Narkhyun bae, Monica Viviano, xiaonan su, Jie Lv, Donghang Cheng, Cari Sagum, Sabrina Castellano, Xue Bai, Claire Johnson, Mahmoud Khalil, Jianjun Shen, KaiFu Chen, Haitao Li, Gianluca Sbardella, Mark T. Bedford. Nature Chemical Biology, 13, 750-756 (2017).
- [2017] A Potential Antitumor Activity and Apoptosis induction of Glossostemon Bruguieri Root Extract against HepG2 Hepatocellular Carcinoma Cells. Mahmoud Khalil, Mohamed Ibrahim, Gehan El-Gaaly, Mona Alwhibi, Ahmed Sultan.; Evidence-Based Complementary and Alternative Medicine Volume (2017), Article ID 7218562, 14 pages.
- [2017] Quercetin Induces Apoptosis in Triple-negative Breast Cancer Cells via Inhibiting Fatty Acid Synthase and β-catenin. Ahmed Sultan, Mahmoud Khalil, Besra Sami, Afrah Alkhuriji, Omayma Sadek. International Journal of Clinical & Experimental Pathology, 10(1):156-172 (2017).
- [2015] Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 & Proliferating Cell Nuclear Antigen. Mahmoud Khalil, M. Ibrahim, G. El-Gaaly, A. Sultan. Biomed Research International. Volume (2015), Article ID 914645, 11 pages
- [2014] S6 Kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo" Ismail, H.; Hurd, P.; Mahmoud Khalil; Kouzarides, T.; Bannister, A.; Gout, I. Journal of Cellular Biochemistry, 115:1048-1062 (2014).
- [2012] Overexpression or Downregulation of mTOR in Mammalian Cell. mTOR: Methods and Protocols Series. Mahmoud Khalil and Gout, I. Book chapter: Methods in Molecular Biology, 821:87-103 (2012).
Industrial and medical microbiology (subtheme)
- [2022] Synthesis, Characterization, and Antibacterial Activity of Mg-Doped CuO Nanoparticles. Molecules. 2022 Dec 23;28(1):103. Russul Adnan, Malak Mezher, Alaa Abdallah, Ramadan Awad, Mahmoud Khalil
- [2020] Novel Biogenic Silver Nanoparticle-Induced Reactive Oxygen Species Inhibit the Biofilm Formation and Virulence Activities of Methicillin-Resistant Staphylococcus aureus (MRSA) Strain. Frontiers Bioeng & Biotechnology. (2020) Volume 8, Article 433. Reham Hamida, Mohamed Ali, Doaa Goda, Mahmoud Khalil, Mayasar Al-Zaban.
- [2015] Detection of shiga-toxin producing E. coli (STEC) in leafy greens sold at local retail markets in Alexandria, Egypt. Rowaida Khalil, Mohamed Gomaa, Mahmoud Khalil. International Journal of Food Microbiology. (2015) 197: 58-64.
Science and Technology Theme:
Environmental studies (subtheme)
- [2020] Fluorescence polarization assay to detect the presence of traces of ciprofloxacin. Scientific Reports. (2020) 10 (1), 1-6. Hiyam Kojok, Nada El Darra, Mahmoud Khalil, Alessandro Capo, Angela Pennacchio, Maria Staiano, Alessandra Camarca, Sabato D’Auria, Antonio Varriale.
Undergraduate Courses
- First Level Medical students: Molecular biology; Genetics
- Second Level Medical students: Recombinant DNA
- Third Level Medical students: Immunology; Genetics.
- Pre-Dentistry, Pre-Pharmacy, and First level Science Courses: Physiology; Cytology; Histology; Genetics; Animal Taxonomy; General Biology
- Second level Science Courses: Cell Biology.
- Third level Science Courses: Molecular Biology (1); Cell Differentiation & Tissue Culture; Micro-techniques and Cellular Imaging; Practical Molecular Biology;
- Fourth level Science Courses: Cell & Tissue Culture; Cellular Signal Transduction; Molecular Biology (2); Molecular Neurobiology; Biotechnology; Bioinformatics; Endocrinology; Developmental Biology; Senior Project.
Postgraduate Courses
Advanced Cell Biology; Signal Transduction; Genomics and Proteomics; Systems Biology; Protein Analysis; Molecular Diagnostics; Mammalian Toxicology; Special Topics in Molecular Biology; Animal Cell culture & Tissue Engineering; Biology of RNA; Advanced Proteomics; Research Techniques; and Independent Studies
- Certified Associate trainer, Training of Trainers (TOT), International Board of Certified Trainers (IBCT).
- Trainer at Faculty and Leadership Development Center (FLDC), Alexandria University, Egypt.
- Member of the organizing Committee for 7th Environmental Forum at the Alexandria University: Climate change and sustainable development objectives.
- (Mar 2019-Present) Representative and coordinator of BAU at the Lebanese Standards Institution – LIBNOR.
- (Jan 2018-Present) Associate certified trainer in the International Board of Certified Trainers (IBCT).
- (June 2017-Present) Lecturer and Trainer at Faculty and Leadership Development Center (FLDC), Alexandria University, EGYPT.
- (23-24 Apr 2016) Organizing Committee for 7th Environmental Forum: Climate change and sustainable development objectives. Alexandria University, EGYPT.
- (2009) Organizing the First Annual Conference for the Egyptian Scholars in United Kingdom.
- (2008-2009) President of the Egyptian Scholars' union in the United Kingdom.
- (Apr 2002) Training at the Pioneers’ Institute (Ministry of Higher Education, EGYPT).
- (1997-Present) Member of the General Egyptian Society for the Talented.
[2019–2022] International Post Graduate Studies in Environmental Management and Sustainability for Mediterranean Countries (ENVIPRO-MED). International Project: Montpellier University and Institute of Research for Development (IRD), France. (Collaborator)
[2016–2018] Novel Bacterial Redox Protein Nanofibers Delivery System: A Promising therapeutic Treatment Strategy for Hepatocellular Carcinoma. National Project: STDF project granted the Egyptian government (Principal Investigator)
[2014–2017] Targeting Therapy for Advanced Hepatocellular Carcinoma stem cells by Novel Microarray. National Project: Alex Rep project granted by Alexandria University, Egypt (Co-Principal Investigator)
[2010–2012] Evaluation of the Microbiological Safety of Fresh Produce Leafy Greens and their Potential Contamination with Escherichia coli serotype O157:H7. National Project: Alex Rep project granted by Alexandria University, Egypt (Collaborator)
[2011–2013] Implementing a Scientific International master for biotechnology and neuroscience in the South Mediterranean Area. International Project: Tempus project " granted by the European Commission (Teacher)