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Doaa Issa

Pharmaceutical Sciences Department

01 300110 Ex: 2796


Doaa Issa

Associate Professor of Medicinal Chemistry

Dr. Doaa is an Associate Professor of Medicinal Chemistry, at the Faculty of Pharmacy in Beirut Arab University. She received her PhD in 2007 through a channel program and joint supervision between Alexandria University, Alexandria, Egypt and Hamburg University, Hamburg, Germany. Her study was supported by a scholarship grant awarded by German Academic Exchange Service (DAAD). Dr. Doaa is also a member in many committees including curriculum, research and postgraduate students, and entrance exam committee. In addition, she is assigned as an executive supervisor of the junior research team at Beirut Arab University. Aside from teaching, Dr. Doaa acted as faculty council and curriculum committee secretary and as acting treasurer of Pharmaceutical Sciences Department at Beirut Arab University.
Prior to teaching at the Faculty of Pharmacy, Dr. Doaa worked as medial representative and as oncology products specialist at Bristol-Myers Squibb Company, Egypt in 1995.
Her main research interests are designing, molecular modeling, synthesizing, developing, verifying and characterizing different heterocyclic compounds of biological significance in the fields of anticancer, antimicrobial, estrogen receptor modulators and anti-inflammatory drugs


Previous courses

Under and postgraduate courses to pharmacy students, Faculty of Pharmacy, University of Alexandria and Beirut Arab University including:
• Pharmaceutical Medicinal Chemistry
• Organic Chemistry

University elective courses at Beirut Arab University including:
• Drugs and Abuse
• PHAR 009 Water Secrets and Life


Research Interest:
Design, molecular modeling, synthesis, development, verification and characterization of different heterocyclic compounds of biological significance in the fields of anticancer, antimicrobial, estrogen receptor modulators, and anti-inflammatory drugs.

Journal Articles
1. Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells
Ahmed Malki, Hayam M. A. Ashour, Rasha Y. Elbayaa, Doaa A. E. Issa, Hassan A. Aziz and Xiaozhuo Chen. J Enzyme Inhib Med Chem, Published online 8 December 2015,
DOI: 10.3109/14756366.2015.1118686

2. Development of mucoadhesive microbeads using thiolated sodium alginate for intrapocket delivery of resveratrol
Abeer Ahmed Kassem, Ragwa Mohamed Farid, Doaa Ahmed Elsayed Issa, Doaa Said Khalil, Mona Yehia Abd-El-Razzak, Hussein Ibrahim Saudi, Heba Mohamed Eltokhey, Enas Arafa El-zamarany. International Journal of Pharmaceutics, 2015, 487, 305–313, DOI:10.1016/j.ijpharm.2015.04.010

3. Design, facile synthesis and anthelmintic activity of new O-substituted 6-methoxybenzo thiazole-2-carbamates
A. Mohsen M. E. Omar, Omaima M. Aboulwafa, Doaa A. E. Issa, May M. S. El-Shokrofy, May E. Amr and Ibrahim M. El-Ashmawy. Med. Chem. Comm., 2015, 6, 5, 795-805, DOI: 10.1039/c4md00557k

4. Design, Synthesis and Biological Evaluation of Novel 1,2,4-Triazolo and 1,2,4-Triazino[4,3-a]quinoxalines as Potential Anticancer and Antimicrobial Agents
Doaa A. E. Issa, Nargues S. Habib and Abeer E. Abdel Wahab. Med. Chem. Comm., 2015, 6, 1, 202-211, DOI: 10.1039/C4MD00257A

5. Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin dependent kinase (CDKs) inhibitory activities
Detlef Geffken, Raafat Soliman , Farid S. G. Soliman, Magdi M. Abdel-Khalek, Doaa A. E. Issa. Med. Chem. Research, 2011, 20, 408–420

1. Doaa A. E. Issa, Bashir S. AlamEddine, Farah H. Mansour, Kawkab I. Rahal, Maya M. AlAriss, Mira H. Safa, Nadine A. Ismail, Rawane J. AlKaaki, Rayane M. Abou hawily, Rawaa M. Sharbaji, Violette H. Fawaz; Design, synthesis and biological evaluation of novel hydroxyalkylpiperidinylpentanol, hydroxyalkylpiperazinylpentanol and their isosteric ethoxyethanol derivatives as potential antidepressants; 21st LAAS International Science Conference «Horizon 2020: Advances in Sciences and Technology» Saint Joseph University (USJ), Damascus Road, Beirut, Lebanon. April 15-17, 2015, PS 2
2. Doaa A. E. Issa , Fatima M. Sleiman, Farah H. Mansour, Sanaa A. Sharari, Mohammad A. Al Mallah, Salma J. Tarabeih; Advances in Drug Discovery of Non-Steroidal Anti-Inflammatory Agents: Medicinal Chemistry Drug Development Prospect; 17th scientific congress of the association of Pharmacy colleges in the Arab world, New trends in drug discovery, development and pharmacy practice, Ain Shams University, Cairo, Egypt. October 14-16, 2014, P 3D
3. A. Malki, H. M. Ashour, D. A. E. Issa, R. Y. Elbayaa, H. A. Aziz, X. Chen; novel 1,5-diphenyl-6-substituted pyrazolo[3,4-d]pyrimidin-4-ones induced apoptosis in colon cancer RKO cells via targeting mitochondrial pathway; 3-rd International Conference of Organic Chemistry (ICOC-2014) “Organic Synthesis - Driving Force of Life Development” - Tbilisi, Georgia. September 25-28, 2014, PP62
4. Doaa A. E. Issa, Hayam M. Ashour and Rasha Y. El Bayaa; Synthesis of some new bioactive pyrazolo[3,4-d]pyrimidine derivatives; 4th International Symposium ASMC 2011, Advances in Synthetic and Medicinal Chemistry, St Petersburg, Russia, August 21-25, 2011, P 047
5. Doaa A. E. Issa, Raafat Soliman, Farid S. G. Soliman, Magdi M. Abdel-khalek, Elsayed A. M. Badawey and Thomas Kappe; Synthesis and Anticancer Evaluation of Certain 2-Furanones and Derived N-Heterocycles; 7th Ibn Sina International Conference of Pure and Applied Hetero cyclic Chemistry - Alexandria, Egypt, March 25-28, 2000, P 82


Journals Peer reviewing
1. Medicinal Chemistry Research
2. Archiv der Pharmazie - Chemistry in Life Science

Attended Conferences
- Appropriate Use of Medication: A Guarantee for A Safety Society Conference Beirut Arab University, Beirut, Lebanon, June 5-6, 2015
- HEALTH INSIGHT 5; Pharmaceutical and Food supplements Business Development Congress 2015 , Dbayeh, Beirut, Lebanon, April, 23-24, 2015
- 21st LAAS International Science Conference «Horizon 2020: Advances in Sciences and Technology» Saint Joseph University, Beirut, Lebanon April 15-17, 2015
- OPL 22nd Pharmaceutical Congress AND Arab Pharmacists Union 29th Congress, Hilton Habtoor Grand Hotel – Sin El Fil October 24-26, 2014
- Scientific research and Higher education, Universities association of Lebanon, UNESCO Palace, Beirut, Lebanon, February 17-18, 2014
- HEALTH INSIGHT 4 ; Pharmaceutical and Food supplements Business Development, Dbayeh, Beirut, Lebanon, March, 27-28, 2014
- Supply Chain Management in the Middle East, the Opportunities and Challenges, Faculty of Business administration, BAU, Beirut, Lebanon December 12, 2013
- Quality through excellence and innovation; The First Scientific Conference of Quality Assurance of Education, Conference Center, University of Cairo, July 29-30, 2009
- Nanoscience and Nanotechnology at a Glance; the first trilateral international symposium organized by the Interdisciplinary Nanoscience Center (iNANO) in Denmark, the National Research Center of Egypt (NRC), and Pharos University in Alexandria (PUA), Egypt, January 15, 2009
- Quality and Accreditation The Present and Prospective; The First International Conference of the Quality Assurance and Accreditation center, University of Cairo, April 15, 2008

Attended Workshops
- 3 Day Training in Bioinformatics & Drug Discovery Technology; Park Inn by Radisson Hotel Apartments, Al Barsha 1, Dubai, United Arab Emirates, April 9-11, 2015
- Research Proposal: Preparation and Analysis; Beirut Arab University, Ali Rashed, Main Building, Beirut, Lebanon, April 9, 16, 23, 30, 2014
- Behavioral Styles; Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon, February 4, 2014
- Small Group Learning, January 24, 2014 Ali Rashed, Main building Medical Education Unit, BAU
- Staff Vs Students Towards Effective Communication , Beirut Arab University, Seminar room, Main Building, Beirut, November 29, 2013
- Mobility Day, Research, Development and Innovation Program (RDI) Faculty of Medicine, University of Alexandria October 21, 2008
- Course Report work Shop, Faculty of Pharmacy, University of Alexandria, June 23, 2008
- Course Specification Work Shop, Faculty of Pharmacy, University of Alexandria, June 19, 2008
- FP7 awareness symposia, held in different faculties University of Alexandria. 2008
- Internationales Stipendiatentreffen des DAAD, Humboldt-Universität, Berlin, July 1-3, 2005
- Attendance of Seminars about Electronic Library, Drug Design and Drug Modeling, Faculty of Pharmacy, University of Alexandria, Egypt


• Distinct High School Student, 1987 Sainte Jeanne Antide, Alexandria, Egypt
• Elected Ideal Pharmacy Student, 1992 Faculty of Pharmacy, University of Alexandria
• Study and Research DAAD grant (Channel-Program)October 2004 – September 2006 Institute of Pharmacy, University of Hamburg, Hamburg, Germany.