Said El Shamieh

Said El Shamieh
Faculty: Health SciencesDepartment: Medical Laboratory TechnologyPosition: Assistant ProfessorPhone: 00961-1-300110Ext: 2721E-mail: s.elshamieh@bau.edu.lb

Biography

Dr. Shamieh obtained a BSc in Medical Laboratory Sciences from the Lebanese University, Lebanon in 2007. Then, in 2009, he earned a M.Sc. in Molecular, cellular and Structural Biology from Lorraine University, France. Subsequently, He was offered a research grant to pursue his PhD in biological sciences at the same University. After completing his PhD in 2012, Dr. Shamieh underwent a 2 years postdoctorate fellowship at the University of Pierre and Marie Curie, Paris, France.
His main research focuses on undergoing genotype - phenotype associations in order to identify genetic variants being implicated in human complex and Mendelian diseases.
In total, Dr. Shamieh has published twenty articles in different peer-reviewed journals, like;  The American Journal of Human Genetics, Human Molecular Genetics, PLoS ONE, Atherosclerosis, International Journal of Cardiology, Clinica Chimica Acta, IOVS and BMC Medical Genetics.
In addition to articles, he is a co-inventor of the patent WO2013093091 revealing specific genetic factors in blood pressure.

Teaching

Fall Courses 2016/2017

- Genetics and Molecular Biology (3 Credits)
- Forensic Biomedicine (2 credits)
- Cancer Biology and Biomedicine (2 Credits)
- Biochemistry (3 Credits)
- Molecular Genetics (1 Credit)
- Mammalian Toxicology (3 Credits)
- Biochemistry (3 Credits)

Publications

1. El Shamieh S, Saleh F, Fawaz M, Farhat F, Siest G, Visvikis-Siest S. Next Generation Sequencing and Immuno-histochemistry profiling identify numerous biomarkers for personalized therapy of endometrioid endometrial carcinoma. Clinical Chemistry and Laboratory Medicine. 2017 Jul 29.

 

2. Akhdar H, El Shamieh S, Musso O, Désert R, Joumaa W, Guyader D, Aninat C, Corlu A, Morel F. The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals. PLoS One. 2016 Dec 9;11(12).

 

3. Audo I, El Shamieh S, Méjécase C, Michiels C, Demontant V, Antonio A, Condroyer C, Boyard F, Letexier M, Saraiva JP, Blanchard S, Mohand-Saïd S, Sahel JS, Zeitz C. ARL2BP mutations account for 0.1% of autosomal recessive rod-cone dystrophies with the report of a novel splice variant. Clinical Genetics. 2016 Oct 28

 

4. Rancier M, Zaaber I, Stathopoulou MG, Chatelin J, Saleh A, Marmouch H, El Shamieh S, Masson C, Murray H, Lamont J, Fitzgerald P, Mahjoub S, Said K, Bel Hadj Jrad Tensaout B, Mestiri S, Visvikis-Siest S. Pro- and anti-angiogenic VEGF mRNAs in autoimmune thyroid diseases. Autoimmunity. 2016 Aug 5:1-7.

 

5. Boulanger-Scemama E, El Shamieh S, Démontant V, Condroyer C, Antonio A, Michiels E, Boyard F, Saraiva JP, Letexier M, Souied E, Mohand-Saïd S, Sahel JA, Zeitz C and Audo I. Next-Generation Sequencing applied to a large French cone and cone-rod dystrophy cohort: mutation spectrum and new genotype-phenotype correlation. Orphanet Journal of Rare Diseases. 2015 Jun 24;10:85.

 

6. Kikuchi S, Kameya S, Gocho K, El Shamieh S, Akeo K, Sugawara Y, Yamaki K, Zeitz C, Audo I, Takahashi H. Cone dystrophy in patient with homozygous RP1L1 mutation. BioMed Research International. 2015:545243.

 

7. El Shamieh S, Boulanger-Scemama E, Lancelot ME, Antonio A, Démontant V, Condroyer C, Letexier M, Saraiva JP, Sahel JA, Audo I, Zeitz C. Targeted next generation sequencing identifies novel mutations in RP1 as a relatively common cause of autosomal recessive rod-cone dystrophy. BioMed Research International. 2015 : 485624.

 

8. El Shamieh S, Neuillé M, Terray A, Orhan E, Condroyer C, Démontant V, Michiels C, Antonio A, Boyard F, Lancelot ME, Letexier M, Saraiva JP, Léveillard T, Mohand-Saïd S, Goureau O, Sahel JA, Zeitz C, Audo I. Whole exome sequencing identifies KIZ as a ciliary gene underlying autosomal recessive rodcone dystrophy. The American Journal of Human Genetics. 2014. Apr 3;94(4):625-33.

 

9. Neuillé M, El Shamieh S, Orhan E, Michiels C, Antonio A, Lancelot ME, Condroyer C, Bujakowska K, Poch O, Sahel JA, Audo I, Zeitz C. Lrit3nob6 a novel mouse model of complete congenital stationary night blindness. PLoS ONE. 2014 Mar 5;9(3).

 

10. Siest G, Ndiaye NC, El Shamieh S, Shahabi P, Stathopoulou M, Saleh AS, Godjo T, Albertini L, Visvikis-Siest S. Conference Scene: Systems biology and personalized health science and translation. Pharmacogenomics. 2013 Dec;14(16):1953-64.

 

11. Orhan E, Prézeau L, El Shamieh S, Bujakowska KM, Michiels C, Zagar Y, Vol C, Bhattacharya SS, Sahel JA, Sennlaub F, Audo I, Zeitz C. Further insights in GPR179: expression, localization and associated pathogenic mechanisms leading to congenital stationary night blindness. Invest Ophthalmol Vis Sci. 2013 Dec 9;54(13):8041-50.

 

12. Audo I, Bujakowska K, Orhan E, El Shamieh S, Sennlaub F, Guillonneau X, Antonio A, Michiels C, Lancelot ME, Letexier M, Saraiva JP, Nguyen H, Luu TD, Léveillard T, Poch O, Dollfus H, Paques M, Goureau O, Mohand-Saïd S, Bhattacharya SS, Sahel JA, Zeitz C. The familial dementia gene revisited: a missense mutation revealed by whole exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family. Human Molecular Genetics, 2013 Jan 15;23(2):491-501.

 

13. Stathopoulou MG, Monteiro P, Shahabi P, Peñas-Lledó E, El Shamieh S, Silva Santos L, Thilly N, Siest G, Llerena A, Visvikis-Siest S. Newly identified synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 rs4244285. International Journal of Cardiology, 2013 Oct 3;168(3):3057-8.

 

14. Nivet-Antoine V, Labat C, El Shamieh S, Dulcire X, Cottart CH, Beaudeux JL, Zannad F, Visvikis- Siest S, Benetos A. Relationship between catalase haplotype and arterial aging. Atherosclerosis, 2013 Mar;227(1):100-5.

 

15. Ndiaye NC, El Shamieh S, Stathopoulou MG, Siest G, Tsai MY, Visvikis-Siest S. Two epistatic interactions may be involved in blood pressure genetic regulation. BMC Genetics, 2013 Jan 8;14:2.

 

16. A common variant highly associated with plasma VEGFA levels also contributes to the variation of both LDL-C and HDL-C. Stathopoulou MG*, Bonnefond A*, Ndiaye NC*, Azimi Nezhad M, El Shamieh S, Saleh A, Rancier M, Siest G, Lamont J, Fitzgerald P, Visvikis-Siest S. Journal of Lipid Research, 2013 Feb;54(2):535-41.

 

17. El Shamieh S, Ndiaye NC, Stathopoulou MG, Murray HA, Masson C, Lamont JV, Fitzgerald P, Benetos A, Visvikis-Siest S. Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels in 8,220 European individuals. PLoS ONE, 2012;7(7).

 

18. El Shamieh S and Visvikis-Siest S. Hypertension genetic biomarkers and future challenges with the emerging of epigenomics. Clinica Chimica Acta, 2012 Dec 24;414:259-65.

 

19. Mangino M, Hwang SJ, Spector TD, Hunt SC, Kimura M, Fitzpatrick AL, Christiansen L, Petersen I, Elbers CC, Harris T, Chen W, Srinivasan SR, Kark JD, Benetos A, El Shamieh S, Visvikis-Siest S, Christensen K, Berenson GS, Valdes AM, Viñuela A, Garcia M, Arnett DK, Broeckel U, Province MA, Pankow JS, Kammerer C, Liu Y, Nalls M, Tishkoff S, Thomas F, Ziv E, Psaty BM, Bis JC, Rotter JI, Taylor KD, Smith E, Schork NJ, Levy D, Aviv A. Genome Wide Association points toward CTC1 and ZNF676 as telomere regulating genes. Human Molecular Genetics, 2012 Dec 15;21(24):5385-94.

 

20. Froguel P, Ndiaye NC, Bonnefond A, Bouatia-Naji N, Dechaume A, Siest G, Herbeth B, Falchi M, Bottolo L, Guéant-Rodriguez RM, Lecoeur C, Langlois MR, Labrune Y, Ruokonen A, El Shamieh S, Stathopoulou MG, Morandi A, Maffeis C, Meyre D, Delanghe JR, Jacobson P, Sjöström L, Carlsson LM, Walley A, Elliott P, Jarvelin MR, Dedoussis GV, Visvikis-Siest S. A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating Haptoglobin levels. PLoS ONE, 2012 ;7(3):e32327.

 

21. Ndiaye NC*, Azimi-Nezhad M*, El Shamieh S*, Stathopoulou MG*, Visvikis-Siest S. Cardiovascular diseases and Genome-Wide Association Studies. Clinica Chimica Acta, 2011 Sep 18;412(1920):1697- 701. * Equal First authors

 

22. Nzietchueng R*, El Shamieh S* Benachour H, Labat C, Herbeth B, Ndiaye NC, Masson C, Visvikis-Siest S, Benetos A. Klotho KL-VS genotype is involved in blood pressure regulation. Clinica Chimica Acta, 2011 Sep 18;412 (19-20):1773-7. * Equal First authors

 

23. El Shamieh S, Herbeth B, Azimi-Nezhad M, Benachour H, Masson C, Visvikis-Siest S. Human formyl peptide receptor 1 C32T SNP is associated with increased blood pressure levels Clinica Chimica Acta, 2010 Jan 18;413(1-2):34-8.

Research Interests

Inherited retinal diseases

Blood pressure

Next generation and Sanger sequencing

Genetic variations (Mutations and SNPs)

Activities

Committees:

2016-2017: Chair of the research committee, faculty of Health Sciences, Beirut Arab University.

2013-2014: Member of the Association for Research in Vision and Ophtalmology.

2011-2016: Member of the European Society of Pharmacogenomics and Theranostics.

Conferences:

A- Invited platform presentations:

2014: Fifth annual Young researchers in Life Sciences conference, Paris, France.

2013: International Society for Genetic Eye Diseases & Retinoblastoma, Ghent, Belgium.

2012: Sixth Santorini International Conference, Santorini, Greece.

2010: Fourth International Meeting of the French Society of Hypertension, Paris, France.

 

B- Poster presentations:

2014: ARVO conference, Orlando, Florida, USA.

2011: 5th International Meeting of the French Society of Hypertension, Paris, France.

2010: 5th Santorini International Conference, Santorini, Greece.

 

Supervisor (thesis): Co-supervisor of two PhD students at BAU.