PHAR 340 Medicinal Chemistry II

PHAR 340 Medicinal Chemistry II

Department offering the course: Pharmaceutical Sciences    
Level [Semester]: Third [Spring]    

Basic Information
Total Credit Hours: 3
Lecture: 2
Practical: 2
Professional Information
Course Description:
The course intends to elaborate fundamentals of medicinal chemistry; it starts with an introduction to physiochemical properties of drugs relative to their biological effects. The course is developed to highlight the concept of drug discovery and development throughout studying chemical and biochemical aspects of certain drug categories including those affecting neurotransmission, local anesthetics, respiratory and gastrointestinal drugs. Satisfactory awareness of the chemistry of antibiotics, antibacterial sulfonamides, quinolones, and antimycobacterial agents is also undertaken. The course helps students to acquire adequate comprehension of potential drug instabilities, interactions and side effects, supporting them meeting patient’s needs. The practical part of the course develops students’ ethical and professional responsibilities and raises their decision-making skills.

Overall aims:
The prime objective of this course is to extend the student professional performance capacities by teaching adequate information about important chemical, biochemical and pharmacotherapeutic aspects of selected medicinal and pharmaceutical agents that treat, alleviate a disorder or regain a proper function of several human body systems. The course also offers to students the opportunity to discover the relevance of chemistry in relation to drug development and improvement of the quality of life.

Pre-requisites: PHAR 273, PHAR 280

Time Table:
Lecture: Tuesday 10-12 am    Wednesday 12-2 pm    
Lab: Wednesday 8-12 am     Thursday 12-4 pm    
Office Hours:    Monday 8-12 am        

Assessment  Methods:
- Written Examination
- Practical Assessments
- Assignments
- Oral Examination

List of References
- An Introduction to Medicinal Chemistry, G. L. Patrick, 4th Ed.,  Oxford, Oxford University Press, 2009
- Foye's Principles of Medicinal Chemistry / W. O. Foyes, David A. Williams, T. L. Lemke, V. F. Roche, S. W. Zito, 7th Ed., Uk: Wolters Kluwer Ltd., Baltimore Lippincott Williams & Wilkins, 2013
- Foye's Principles of Medicinal Chemistry, W. O. Foyes, D. A. Williams and T. L. Lemke, V. F. Roche, S. W. Zito, 6th Ed., Uk : Wolters Kluwer Ltd., Baltimore, Lippincott Williams & Wilkins, 2008
- Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry, J. H. Block, J. M. Beale, 11th Ed., Philadelphia, Lippincott Williams & Wilkins, 2004

Further reading:
- Burger's Medicinal Chemistry and Drug Discovery, 6th Ed., Donald J. Abraham., New Jersey : John Wiley & Sons, Inc., 2003
- British Pharmacopoeia 2003, B.P. Commission Office, Crown 2003