CHEM 418 - Medicinal Chemistry

Analysis of Organic Compounds - CHEM 418

Lecture Meeting: Wednesday 12:30 - 14:30

Catalog Description:

Classification of drugs. Drug action at enzymes, receptors and nucleic acids. Pharmacodynamics. Quantitative Structure - Activity Relationships (QSAR). Antibacterial agents, anticancer and peripheral nervous system drugs.

Course Objectives:

The aim of this course is to introduce students to introduce students to the basics of medicinal chemistry. The course will start by highlighting the various steps in the drug design and development process. Then the course will touch on lipids and carbohydrates as drug targets before moving to in depth discussion of proteins as drug targets. The role of enzymes in biological reactions will be discussed, and the design of various enzyme inhibitors will be detailed. The design of anti-nucleic acid drugs will also be discussed. Pharmacokinetic properties of drugs and chemical factors affecting it will be analyzed. Finally, drug delivery approaches will be introduced.

Intended Learning Outcomes (ILO’s)


    Knowledge and understanding:


        K1- State the basic steps in the drug design and development process.

        K2- Classify drugs based on its mode of action.

        K3- Identify the pharmacokinetic properties of drugs.

        K4- List the various types of drug delivery methods.

    Intellectual abilities:

        I1- Differentiate between the different types of enzyme inhibitors.

        I2- Determine the role of chemical functional groups in affecting drug-receptor interactions.

        I3- Predict the ADME properties of drugs.

        I4- Calculate inihibition constants and reaction rates.

    Professional and Practical competencies:

        P1- Solve problems associated with drug action.

        P2- Sketch Lineweaver-Burke and Schild analysis plots.

        P3- Design drugs with improved therapeutic profiles.

    General and Transferable Skills:

        S1- Communicate scientific information in English.

        S2- Rationally think and solve problems.

        S3- Use the library and e-resources to access information.

        S4- Work in groups and communicate with others positively.

Download course syllabus as PDF