Mohammad Dakdouki

Mohammad Dakdouki
Faculty: ScienceDepartment: ChemistryPosition: Associate Professor of Organic ChemistryOffice Number: B217 (A3 building)Phone: +961 7 985 858Ext: 3348E-mail: m.eldakdouki@bau.edu.lb

Biography

Dr. Mohammad H. El-Dakdouki completed a Bachelor of Science degree in Chemistry from the Lebanese University in June 2001. He then joined the Chemistry MS program at the American University of Beirut in September 2002 where he worked under the supervision of Prof. Makhlouf J. Haddadin, the co-inventor of the internationally acknowledged Beirut Reaction and the Davis-Beirut Reaction. During his MS thesis, Dr. El-Dakdouki worked on the development of the Davis-Beirut Reaction that led to the synthesis of novel heterocyclic compounds. He successfully completed the MS degree in Organic Chemistry in June 2004. Dr. El-Dakdouki joined the PhD program in the College of Pharmacy at The University of Toledo (USA) where he worked under the supervision of Prof. Paul W. Erhardt, the inventor of the commercial drug Esmolol. Dr. El-Dakdouki worked on the development of anticancer drugs with reduced multidrug resistance liability. He graduated with a PhD degree in Medicinal and Biological Chemistry in December 2009. Dr. El-Dakdouki joined Prof. Xuefei Huang group at Michigan State University (USA) as a postdoctoral fellow from September 2009 till August 2011, and as a Research Assistant Professor from September 2011 till August 2012. During his stay at Michigan State University, Dr. El-Dakdouki utilized nanotechnology, organic synthesis, molecular imaging, and biological assessment for the detection, diagnosis, and treatment of diseases such as cancer, Alzheimer, and atherosclerosis. Dr. El-Dakdouki joined Beirut Arab University as Assistant Professor of Organic and Biological Chemistry in September 2012, and was promoted to Associate Professor in August 2015. Dr. El-Dakdouki published around 30 peer reviewed articles and book chapters, and acts as reviewer for several high impact international journals.  

Download CV

Teaching

Previous courses

Undergraduate Courses (current and previous):

Organic Chemistry (I and II), Bioorganic Chemistry, Industrial Organic Chemistry, Pharmaceutical Organic Chemistry, Analysis of Organic Compounds, Physical Organic Chemistry, Medicinal Chemistry, Chemistry of Biomolecules.

Graduate Courses (current and previous):

Advanced Organic Chemistry, Advanced Organic Reactions, Advanced Instrumental Analysis, The Organic Chemistry of Drug Design and Development, Diseases and Natural Products.

Spring 2015/2016

Research

Research Interests

- Synthesis of heterocyclic compounds for the detection of Alzheimer’s disease.

- Examining the effect of natural product analogues on preventing Alzheimer’s disease.

- Deploying nanomaterials for the targeted anticancer drug delivery and tumor imaging.

- Development of novel nanoparticles for high cell labeling efficiency.

- Deploying biomaterials and biopolymers for selective drug delivery.

- Exploiting magnetic nanoparticles for the early detection of atherosclerotic plaques.

- Surveying natural products (plant and animal sources) for various biological activities.

- Detection of pollutants in the environment.

Publications

1.    El-Dakdouki, M.H.; Hussein, A.S.; Abdallah, H.; Shatila, R.; Mouneimne, Y. Synthesis of novel 2H-indazole analogues via the Davis-Beirut reaction and conjugation onto magnetic nanoparticles. Tetrahedron. 2017. 73, 5769-5777.

2.    Hammud, H.H.; El-Dakdouki, M.H.; Sonji, N.; Sonji G.; Bouhadir, K.H. Interactions of some divalent metal ions with thymine and uracil thiosemicarbazide derivatives. Nucleosides, Nucleotides and Nucleic Acids. 2016. 35, 259-276.  

3.    Thapa, R.; Galoforo, S.; Kandel, S.M.; El-Dakdouki, M.H.; Wilson, T.G.; Huang, X.; Roth, B.J.; Wilson, G.D. Radiosensitizing and hyperthermic properties of hyaluronan conjugated, dextran-coated ferric oxide nanoparticles: Implications for cancer stem cell therapy. J. Nanomaterials. 2015, DOI:10.1155/2015/840594.

4.    Vyas, D.; Lopez-Hisijos, N.; Gandhi, S.; El-Dakdouki, M.H.; Basson, M.D.; Walsh, M.F.; Huang, X.; Vyas, A.K.; Chaturvedi, L.S. Doxorubicin-Hyaluronan conjugated super-paramagnetic iron oxide nanoparticles (DOX-HA-SPION) enhanced cytoplasmic uptake of Doxorubicin and modulated apoptosis, IL-6 release and NF-kappaB activity in human MDA-MB-231 breast cancer cells. J. Nanosci. Nanotechnol. 2015, 15, 6413–6422.

5.    Dulaney, S.B.; Xu, Y.; Wang, P.; Tiruchinapally, G.; Wang, Z.; Kathawa, J.; El-Dakdouki, M.H.; Yang, B.; Liu, J.; Huang, X. Divergent synthesis of heparan sulfate oligosaccharides. J. Org Chem. 2015, 80, 12265-12279.

6.    El Haj Moussa, A.; Olama, Z.; Moussad, E; Kavunja, H.; El-Dakdouki, M.H. Characterization of Anuran Skin Peptides: An alternative to the classical therapeutic agents used for MDR pathogens. Int. J. Microbio. Appl. Sci. 2015, 4.

7.    El Haj Moussa, A.; El-Dakdouki, M.H.; Olama, Z.; Moussad, E. Antimicrobial effect of Rana ridibunda skin gland peptides against multidrug resistant pathogens. Int. J. Microbio. Appl. Sci. 2015, 4, 62-74.

8.    Hammud, H.H.; El-Dakdouki, M.H.; Sonji, N.; Bouhadir, K.H. Solvatochromic absorption and fluorescence studies of adenine, thymine, and uracil thio-derived acyclonucleosides. Eur. J. Chem. 2015, 6, 325-336.

9.    Borjac, J.; Dannaoui, R.; Saab, H.; El-Dakdouki, M.H.; El-Sibai, M.; Usta, J. Effect of Carboplatin and Methotrexate on Lipid Levels in the Plasma Membrane of MCF-7 Cells and their Association with Cell Motility. Int. J. Biochem. Rev. 2015, 8, 1-12.

10.    Hammud, H.H.; El-Dakdouki, M.H.; Sonji, N.; Sonji G.; Bouhadir, K.H. A novel multi-functional fluorescent probe for Cu2+, Fe3+ and Ag+ based on a pyrimidine thiourea derivative. Curr. Anal. Chem. 2015, 11, DOI: 10.2174/1573411011666150324231041.

11.    El-Dakdouki, M.H.; Xia, J.; Zhu, D.C.; Kavunja, H.; Grieshaber, J.; O’Reilly, S.; McCormick, J.J.; Huang, H. Assessing the efficacy of colloidally stable nanoparticles loaded with doxorubicin in vivo. ACS Appl. Mat. Inter. 2014, 6, 697-705.

12.    El-Dakdouki, M.H.; El-boubbou, K.; Kamat, M.; Huang, R.; Abela, G.S.; Kiupel, M.; Zhu, D.C.; Huang, X. CD44 targeted magnetic glyconanoparticles for atherosclerotic plaque imaging. Pharm. Res. 2014, 31, 1426-1437.

13.    El-Dakdouki, M.H.; Kavunga, H.; Xia, J.; El-Boubbou, K.; Huang, X. Methods for magnetic nanoparticles synthesis and functionalization. Chemistry of Bioconjugates: Synthesis, Characterization and Biomedical Applications, Editor: Ravin Narain, Wiley & Sons, 2014, 281-314.

14.    El-Dakdouki, M.H.; Puré, E.; Huang, X. Development of drug-loaded nanoparticles for tumor targeting. Part 1: synthesis, characterization, and biological evaluation in 2D cell cultures. Nanoscale. 2013, 5, 3895-3903.

15.    El-Dakdouki, M.H.; Puré, E.; Huang, X. Development of drug loaded nanoparticles for tumor targeting. Part 2: enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models. Nanoscale. 2013, 5, 3904-3911.

16.    Kouyoumdjian, H.; Zhu, D.; El-Dakdouki, M.H.; Lorenz, K.; Chen, J.; Li, W.; Huang, X. Glyconanoparticle aided detection of β-amyloid by magnetic resonance imaging and attenuation of β-amyloid induced cytotoxicity. ACS Chem. Neurosci. 2013, 4, 575-584.

17.    El-Dakdouki, M.H.; Zhu, D.C.; El-Boubbou, K.; Kamat, M.; Chen, J.; Li, W.; Huang, X. Development of multifunctional hyaluronan-coated nanoparticles for imaging and drug delivery to cancer cells. Biomacromolecules, 2012, 13, 1144-1151.

18.    El-Dakdouki, M.H.; Erhardt, P.W. Analogue-based drug discovery: More than just a practical approach toward obtaining new drugs. Microtubule stabilizers as a case in point. Pure Appl. Chem. 2012, 84, 1479-1542. Lead article of July 2012 issue.

19.    Yang, B.; Yoshida, K.; Yin, Z.; Dai, H.; Kavunja, H.; El-Dakdouki, M.H.; Sungsuwan, S.; Dulaney, S.B.; Huang, X. Chemical synthesis of a heparan sulfate glycopeptide: Syndecan-1. Angwe. Chem. Int. Ed. 2012. 51, 10185-10189.

20.    Avila, B.; El-Dakdouki, M.H.; Nazer, M.Z.; Harrison, J.G.; Tantillo, D.J.; Haddadin; M.J.; Kurth, M.J. Acid and base catalyzed Davis-Beirut reaction: Experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles. Tetrahedron Lett. 2012, 53, 6475-6478.

21.    Li, H.*; El-Dakdouki, M.H.*; Zhu, D.C.; Abela, G.S.; Huang, X. Synthesis of -CD conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals. Chem .Comm.2012, 48, 3385-3387. Equal contributions. This article was highlighted on the back cover of the issue.

22.    El-Dakdouki, M.H.; Adamski, N.; Foster, L.; Hacker, M.; Erhardt, P.W. Synthesis of 9-aza-anthrapyrazole N-oxide analogues as potential anticancer prodrugs targeting hypoxic cancer cells, J. Med. Chem. 2011, 54, 8224-8227.

23.     Luniwal A.; Khupse, R.; Reese, M.; Liu, J.; El-Dakdouki, M.H.; Malik, N.;  Fang, L.; Erhardt, P.W. Multigram synthesis of glyceollin I. Org. Proc. Res. Devel., 2011, 15, 1149–1162.

24.    El-Dakdouki, M.H.; El-Boubbou, K.; Zhu, D.C.; Huang, X. A simple method for the synthesis of hyaluronic acid coated magnetic nanoparticles for highly efficient cell labelling and in vivo imaging, RSC Advances, 2011, 1, 1449-1452.

25.    Tiruchinapally, G.; Yin, Z.; El-Dakdouki, M.H.; Wang, Z.; Huang, X. Divergent heparin oligosaccharide synthesis with pre-installed sulfate esters. Chem. Eur. J. 2011, 17, 10106-10112.

26.    El-Dakdouki, M.H.; Huang, X. Biological applications of hyaluronic acid functionalized nanomaterials. In Petite and Sweet: Glyco-nanotechnology as a bridge to new medicines, Editors: Huang, X.; Barchi, J. American Chemical Society, 2011, 181-213.

27.    Xie, Z.H.; Tan, W-M.; Qin, A-H.; Dai, H.; Hou, X-T. El-Dakdouki, M.H.  Clinical study of JueMing Hainan Holly Tea. Chinese J. Exper. Trad. Med. Formulae. 2011, 17, 230-235.
28.    El-Dakdouki, M.H.; Erhardt, P.W. Paclitaxel Analogs. In Analogue-based Drug Discovery II, Editors: Fischer, J.; Ganellin, C.R., Wiley-VCH Verlag GmbH & Co. KGaA, 2010, 243-267.

Activities

- Lebanese Association for Advanced Research (LAAS) reviewer, 2015-present.

- American Chemical Society, member, 2005-present.

- Beirut Arab University, University’s Scientific Research Committee, 2013-present.

- Beirut Arab University, University’s Continuing Education Steering Committee, 2013-present.

- Volunteer Judge at for the “Science Competition”.

- Contributed in the process of BAU’s Institutional Accreditation during the site visit of the accreditation board of the Foundation for International Business Administration Accreditation (FIBAA) in October 2014.

- Contributing towards the accreditation of Chemistry program at BAU.

Awards

- Research Grant, Beirut Arab University, 2014.

- Research Grant, National Council for Scientific Research (CNRS), Lebanon, 2013.

- Robert N. Whiteford Memorial Scholarship, University of Toledo, 2008.

- ACS Travel award, 31th National Medicinal Chemistry Symposium 2008, University of Pittsburgh, June 2008.

- Travel award, BioOhio 2008 Annual Conference, Dublin, Ohio, October 2008.

- MAGSS Travel award, 41th Mid Atlantic Graduate Students Symposium in Medicinal Chemistry, Wayne State University, Detroit, July 2008.