This course examines selected clinical concepts from their scientific and theoretical bases. Theoretical issues related to the application of concepts across different settings will be addressed. Students will be introduced to the process of concept analysis. Emphasis is placed on selected medical surgical functional alterations and its related nursing assessment and intervention. Examples will include: homeostais, immobility, pain, inflammation, ischemia, hypoxia, dyspnea, oedema, fatigue, impaired wound healing, allergic reactions, impaired immune competence and altered clotting.