The present course provides in-depth exposure to the principles of biochemistry most important to an understanding of health and disease. Major topics include an introduction to the chemistry of the major classes of biomolecules, including proteins, carbohydrates, lipids, enzymes and nucleic acids. An in-depth review of cell metabolism and how it is regulated at the level of the cell and the whole organism will follow the chemistry of biomolecules. Finally, several metabolic disorders will be explained to contrast normal and perturbed human biochemistry as well as demonstrate the clinical implications of human biochemistry. Therefore, this course is designed for students who are more likely to pursue the medical professions.